Engaging neuroscience to advance translational research in brain barrier biology
Identifieur interne : 001949 ( Main/Exploration ); précédent : 001948; suivant : 001950Engaging neuroscience to advance translational research in brain barrier biology
Auteurs : Edward A. Neuwelt [États-Unis] ; Björn Bauer [États-Unis] ; Christoph Fahlke [Allemagne] ; Gert Fricker [Allemagne] ; Constantino Iadecola [États-Unis] ; Damir Janigro [États-Unis] ; Luc Leybaert [Belgique] ; Zoltán Molnar [Royaume-Uni] ; Martha E. O'Donnell [États-Unis] ; John T. Povlishock [États-Unis] ; Norman R. Saunders [Australie] ; Frank Sharp [États-Unis] ; Danica Stanimirovic [Canada] ; Ryan J. Watts [États-Unis] ; Lester R. Drewes [États-Unis]Source :
- Nature reviews. Neuroscience : (Print) [ 1471-003X ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and-when barrier integrity is impaired-in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
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Affiliations:
- Allemagne, Australie, Belgique, Canada, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Basse-Saxe, District de Karlsruhe, Oxfordshire, Province de Flandre-Orientale, État de New York
- Gand, Hanovre, Heidelberg, Oxford
- Université d'Oxford, Université de Gand
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Le document en format XML
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Neuwelt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oregon Health & Science University, 3181 SW Sam Jackson Park Road L603</s1><s2>Portland, Oregon 97239-2941</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Portland, Oregon 97239-2941</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Portland Veterans Affairs Medical Center, 3710 SW U.S. Veterans Hospital Road</s1><s2>Portland, Oregon 97239</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Portland, Oregon 97239</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Bjorn" sort="Bauer, Bjorn" uniqKey="Bauer B" first="Björn" last="Bauer">Björn Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Minnesota, College of Pharmacy, 1110 Kirby Drive, 232 Life Science</s1><s2>Duluth, Minnesota 55812-3003</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duluth, Minnesota 55812-3003</wicri:noRegion></affiliation></author><author><name sortKey="Fahlke, Christoph" sort="Fahlke, Christoph" uniqKey="Fahlke C" first="Christoph" last="Fahlke">Christoph Fahlke</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut für Neurophysiologie, OE 4230, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1</s1><s2>30625 Hannover</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Fricker, Gert" sort="Fricker, Gert" uniqKey="Fricker G" first="Gert" last="Fricker">Gert Fricker</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Abteilung Pharmazeutische Technologie und Pharmakologie Im Neuenheimer, University of Heidelberg, Feld 366 D</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Iadecola, Constantino" sort="Iadecola, Constantino" uniqKey="Iadecola C" first="Constantino" last="Iadecola">Constantino Iadecola</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Neurobiology, Weill Cornell Medical College, 407 East 61st Street, RR-303, New York</s1><s2>New York 10065</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Janigro, Damir" sort="Janigro, Damir" uniqKey="Janigro D" first="Damir" last="Janigro">Damir Janigro</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Cleveland Clinic Foundation, 9500 Euclid Avenue, Mail Code NB20</s1><s2>Cleveland, Ohio 44195-0001</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, Ohio 44195-0001</wicri:noRegion></affiliation></author><author><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Basic Medical Sciences, Ghent University, De Pintelaan 185</s1><s2>9000 Ghent</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Molnar, Zoltan" sort="Molnar, Zoltan" uniqKey="Molnar Z" first="Zoltán" last="Molnar">Zoltán Molnar</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road</s1><s2>Oxford, OX1 3QX</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oxford, OX1 3QX</wicri:noRegion><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="O Donnell, Martha E" sort="O Donnell, Martha E" uniqKey="O Donnell M" first="Martha E." last="O'Donnell">Martha E. 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Saunders</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pharmacology Parkville, University of Melbourne</s1><s2>Victoria 3010</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation></author><author><name sortKey="Sharp, Frank" sort="Sharp, Frank" uniqKey="Sharp F" first="Frank" last="Sharp">Frank Sharp</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>UC Davis MIND Institute, University of California at Davis, 2825 50th Street</s1><s2>Sacramento, California 95817-2310</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Sacramento, California 95817-2310</wicri:noRegion></affiliation></author><author><name sortKey="Stanimirovic, Danica" sort="Stanimirovic, Danica" uniqKey="Stanimirovic D" first="Danica" last="Stanimirovic">Danica Stanimirovic</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Road</s1><s2>Ottawa, ONK1AOR7</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ONK1AOR7</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Ryan J" sort="Watts, Ryan J" uniqKey="Watts R" first="Ryan J." last="Watts">Ryan J. Watts</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neuroscience, Genentech, 1 DNA Way</s1><s2>South San Francisco, California, 94080-4990</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>South San Francisco, California, 94080-4990</wicri:noRegion></affiliation></author><author><name sortKey="Drewes, Lester R" sort="Drewes, Lester R" uniqKey="Drewes L" first="Lester R." last="Drewes">Lester R. 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Neuwelt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Oregon Health & Science University, 3181 SW Sam Jackson Park Road L603</s1><s2>Portland, Oregon 97239-2941</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Portland, Oregon 97239-2941</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Portland Veterans Affairs Medical Center, 3710 SW U.S. Veterans Hospital Road</s1><s2>Portland, Oregon 97239</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Portland, Oregon 97239</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Bjorn" sort="Bauer, Bjorn" uniqKey="Bauer B" first="Björn" last="Bauer">Björn Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Minnesota, College of Pharmacy, 1110 Kirby Drive, 232 Life Science</s1><s2>Duluth, Minnesota 55812-3003</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duluth, Minnesota 55812-3003</wicri:noRegion></affiliation></author><author><name sortKey="Fahlke, Christoph" sort="Fahlke, Christoph" uniqKey="Fahlke C" first="Christoph" last="Fahlke">Christoph Fahlke</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institut für Neurophysiologie, OE 4230, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1</s1><s2>30625 Hannover</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Fricker, Gert" sort="Fricker, Gert" uniqKey="Fricker G" first="Gert" last="Fricker">Gert Fricker</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Abteilung Pharmazeutische Technologie und Pharmakologie Im Neuenheimer, University of Heidelberg, Feld 366 D</s1><s2>69120 Heidelberg</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Iadecola, Constantino" sort="Iadecola, Constantino" uniqKey="Iadecola C" first="Constantino" last="Iadecola">Constantino Iadecola</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Division of Neurobiology, Weill Cornell Medical College, 407 East 61st Street, RR-303, New York</s1><s2>New York 10065</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Janigro, Damir" sort="Janigro, Damir" uniqKey="Janigro D" first="Damir" last="Janigro">Damir Janigro</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Cleveland Clinic Foundation, 9500 Euclid Avenue, Mail Code NB20</s1><s2>Cleveland, Ohio 44195-0001</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland, Ohio 44195-0001</wicri:noRegion></affiliation></author><author><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Basic Medical Sciences, Ghent University, De Pintelaan 185</s1><s2>9000 Ghent</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Molnar, Zoltan" sort="Molnar, Zoltan" uniqKey="Molnar Z" first="Zoltán" last="Molnar">Zoltán Molnar</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road</s1><s2>Oxford, OX1 3QX</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Oxford, OX1 3QX</wicri:noRegion><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="O Donnell, Martha E" sort="O Donnell, Martha E" uniqKey="O Donnell M" first="Martha E." last="O'Donnell">Martha E. O'Donnell</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Physiology and Membrane Biology, School of Medicine, University of California, One Shields Avenue</s1><s2>Davis, California 95616</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Davis, California 95616</wicri:noRegion></affiliation></author><author><name sortKey="Povlishock, John T" sort="Povlishock, John T" uniqKey="Povlishock J" first="John T." last="Povlishock">John T. Povlishock</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Anatomy and Neurobiology, Virginia Commonwealth University, P.O. Box 980709</s1><s2>Richmond, Virginia 23298-0709</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, Virginia 23298-0709</wicri:noRegion></affiliation></author><author><name sortKey="Saunders, Norman R" sort="Saunders, Norman R" uniqKey="Saunders N" first="Norman R." last="Saunders">Norman R. Saunders</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pharmacology Parkville, University of Melbourne</s1><s2>Victoria 3010</s2><s3>AUS</s3><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation></author><author><name sortKey="Sharp, Frank" sort="Sharp, Frank" uniqKey="Sharp F" first="Frank" last="Sharp">Frank Sharp</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>UC Davis MIND Institute, University of California at Davis, 2825 50th Street</s1><s2>Sacramento, California 95817-2310</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Sacramento, California 95817-2310</wicri:noRegion></affiliation></author><author><name sortKey="Stanimirovic, Danica" sort="Stanimirovic, Danica" uniqKey="Stanimirovic D" first="Danica" last="Stanimirovic">Danica Stanimirovic</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Road</s1><s2>Ottawa, ONK1AOR7</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ONK1AOR7</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Ryan J" sort="Watts, Ryan J" uniqKey="Watts R" first="Ryan J." last="Watts">Ryan J. Watts</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Neuroscience, Genentech, 1 DNA Way</s1><s2>South San Francisco, California, 94080-4990</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>South San Francisco, California, 94080-4990</wicri:noRegion></affiliation></author><author><name sortKey="Drewes, Lester R" sort="Drewes, Lester R" uniqKey="Drewes L" first="Lester R." last="Drewes">Lester R. Drewes</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of Minnesota Medical School, Duluth, 1035 University Drive</s1><s2>Duluth, Minnesota 55812</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Duluth, Minnesota 55812</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Nature reviews. Neuroscience : (Print)</title><title level="j" type="abbreviated">Nat. rev., Neurosci. : (Print)</title><idno type="ISSN">1471-003X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature reviews. Neuroscience : (Print)</title><title level="j" type="abbreviated">Nat. rev., Neurosci. : (Print)</title><idno type="ISSN">1471-003X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Blood CSF barrier</term><term>Blood brain barrier</term><term>Blood flow</term><term>Central nervous system</term><term>Cerebrospinal fluid</term><term>Encephalon</term><term>Parkinson disease</term><term>Review</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Barrière hématoencéphalique</term><term>Barrière sang liquide céphalorachidien</term><term>Liquide céphalorachidien</term><term>Débit sanguin</term><term>Système nerveux central</term><term>Accident cérébrovasculaire</term><term>Article synthèse</term><term>Démence d'Alzheimer</term><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and-when barrier integrity is impaired-in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Karlsruhe</li><li>Oxfordshire</li><li>Province de Flandre-Orientale</li><li>État de New York</li></region><settlement><li>Gand</li><li>Hanovre</li><li>Heidelberg</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Gand</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Neuwelt, Edward A" sort="Neuwelt, Edward A" uniqKey="Neuwelt E" first="Edward A." last="Neuwelt">Edward A. Neuwelt</name></noRegion><name sortKey="Bauer, Bjorn" sort="Bauer, Bjorn" uniqKey="Bauer B" first="Björn" last="Bauer">Björn Bauer</name><name sortKey="Drewes, Lester R" sort="Drewes, Lester R" uniqKey="Drewes L" first="Lester R." last="Drewes">Lester R. Drewes</name><name sortKey="Iadecola, Constantino" sort="Iadecola, Constantino" uniqKey="Iadecola C" first="Constantino" last="Iadecola">Constantino Iadecola</name><name sortKey="Janigro, Damir" sort="Janigro, Damir" uniqKey="Janigro D" first="Damir" last="Janigro">Damir Janigro</name><name sortKey="Neuwelt, Edward A" sort="Neuwelt, Edward A" uniqKey="Neuwelt E" first="Edward A." last="Neuwelt">Edward A. Neuwelt</name><name sortKey="O Donnell, Martha E" sort="O Donnell, Martha E" uniqKey="O Donnell M" first="Martha E." last="O'Donnell">Martha E. O'Donnell</name><name sortKey="Povlishock, John T" sort="Povlishock, John T" uniqKey="Povlishock J" first="John T." last="Povlishock">John T. Povlishock</name><name sortKey="Sharp, Frank" sort="Sharp, Frank" uniqKey="Sharp F" first="Frank" last="Sharp">Frank Sharp</name><name sortKey="Watts, Ryan J" sort="Watts, Ryan J" uniqKey="Watts R" first="Ryan J." last="Watts">Ryan J. Watts</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Fahlke, Christoph" sort="Fahlke, Christoph" uniqKey="Fahlke C" first="Christoph" last="Fahlke">Christoph Fahlke</name></region><name sortKey="Fricker, Gert" sort="Fricker, Gert" uniqKey="Fricker G" first="Gert" last="Fricker">Gert Fricker</name></country><country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Molnar, Zoltan" sort="Molnar, Zoltan" uniqKey="Molnar Z" first="Zoltán" last="Molnar">Zoltán Molnar</name></region></country><country name="Australie"><noRegion><name sortKey="Saunders, Norman R" sort="Saunders, Norman R" uniqKey="Saunders N" first="Norman R." last="Saunders">Norman R. Saunders</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Stanimirovic, Danica" sort="Stanimirovic, Danica" uniqKey="Stanimirovic D" first="Danica" last="Stanimirovic">Danica Stanimirovic</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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